Born in New Haven, Connecticut, to Rebecca Andrews and Myer Moses, animmigrant from England, Isaac grew up with his six siblings inCharleston. In 1802 he married Hannah Lazarus, daughter of Mark andRicha Benjamin Lazarus, and they raised their twelve children inCharleston. Listed in Charleston directry as a justice of the peacein 1819, the following year Isaac founded a law firm with ChristianStanley. He helped found the Reformed Society of Israelites togetherwith dramatist and editor Isaac Harby, whose daughter Octaviamarried Moses’s son, Andrew.His daughter Cecilia married the painter TheodoreSidney Moise, who painted portraits of IsabelMordecai and Isaac’s granddaughter CarolineLopez. While in Branford, Connecticut, Isaac and Hannah werethrown from a buggy, and Isaac died, making him the first known Jewto be buried in Connecticut, while Hannah died the following yearfrom her injuries.